A number of targeted therapies have been approved for use in RCC, including tyrosine kinase inhibitors (TKIs) with anti-angiogenic activity (sunitinib, pazopanib, sorafenib, and axitinib), the VEGF-targeted monoclonal antibody bevacizumab, and the mTOR inhibitors everolimus and temsirolimus [11]. The gene discussed is VEGFA; the disease is renal cell carcinoma.