On the basis of this evidence, in this work, we analyzed the urinary excretion of AQP1, AQP2, and AQP5 in three groups of patients: 12 diabetic with no sign of nephropathy (DM), 12 diabetic with histologic diagnosis of diabetic nephropathy (DN), and 11 diabetic with nondiabetic nephropathy (NDN). The gene discussed is AQP1; the disease is Nephropathy.