As expected, our results demonstrated a higher AUC of 0.928 and 0.878, higher sensitivity of 87% and 85%, and higher specificity of 79% and 70% for predicting DVT and metastasis, respectively, than those of single TFPI-1 measurements, indicating that combining TFPI-1 and D-D measurements may serve as more useful tool in prediction of DVT and metastasis of NSCLC patients. Here, TFPI is linked to deep vein thrombosis.