And our study also demonstrated that TFPI-1 levels were positively and negatively correlated with AT, D-D, Fbg, and FVIII:C levels, respectively, which further indicated that decreased TFPI-1 was closely associated with blood coagulation abnormalities in NSCLC patients, and lower TFPI-1 may have a lower inhibitory power on initial activation of extrinsic coagulation pathway. This evidence concerns the gene TFPI and non-small cell lung carcinoma.