Multivariate regression analysis showed that TFPI-1 had a higher OR value in predicting DVT or metastasis than D-D, Fbg, AT, and FVIII in NSCLC patients, respectively, which indicated that TFPI-1 was a stronger risk factor of DVT and tumor metastasis and also further confirmed that decreased TFPI-1 levels might be correlated with DVT and tumor metastasis in NSCLC patients. The gene discussed is TFPI; the disease is deep vein thrombosis.