Logistic regression analyses showed that TFPI-1 was the independent risk factor related to DVT and tumor metastasis in NSCLC patients (odds ratio, 3.651; 95% confidence interval, 3.011~4.378, P = 0.00; odds ratio, 3.122; 95% confidence interval, 2.620~3.781, P = 0.00, resp). The gene discussed is TFPI; the disease is neoplasm.