TMPRSS3 and Hearing impairment: Exceptions were observed in the TMPRSS3 gene, which was reported to be associated with two different phenotypes: DFNB10-associated hearing impairment has been reported to be prelingual (OMIM 605511), whereas DFNB8-associated hearing impairment is typically late onset and postlingual (OMIM 601072). TMPRSS3 mutations can be classified as mild or severe, and the hearing phenotype is dependent on the combination of the two TMPRSS3 mutant alleles [2].