TMPRSS3 and hearing loss disorder: These data, together with the clinical presentation of the affected siblings and consistent autosomal recessive inheritance of the mutations in the affected and unaffected members, indicate that the TMPRSS3 mutations, p.Ala306Thr, p.Arg106Cys, and p.(Phe13Serfs∗12), are the cause of hearing impairment in this family.