In addition, our previous studies also have shown that TGF-β3 presents antagonistic role of TGF-β1 and TGF-β2; at the cellular level and experimental disease models, TGF-β3 could inhibit the gene expression of TGF-β1 and showed significant inhibition of hepatic fibrosis [20]. This evidence concerns the gene TGFB1 and Hepatic fibrosis.