TGFB1 and Hepatic fibrosis: TGF-β3 is confirmed to be antifibrosis factor, while TGF-β1 is recognized as promoting factor of liver fibrosis; due to their opposite roles in the formation of fibrosis, the early expression imbalance of TGF-β1 and TGF-β3 is consequently believed to lead to early and rapid fibrosis formation in the disease.