TGFB3 and cirrhosis of liver: In conclusion, our study suggested that abnormal activation of HSC was accompanied by imbalance of TGF-β1 and TGF-β3 expression in the early stage of acute autoimmune liver damage induced by injecting ConA in mice, which can link immune and hepatic fibrosis processes, leading to further switching and progressing of liver fibrosis, which may be one of the mechanisms involved in the easy progressing of liver cirrhosis in patients with autoimmune hepatitis.