Protein phosphatase 2 subunit B isoform alpha (PPP2R2A) is one of the four major Ser/Thr phosphatases and is a potential tumor suppressor gene [106], PP2, regulatory subunit B, epsilon isoform (PPP2R5E) expression are usually downregulated in cancer tissue and represses cell viability and growth promoting apoptosis in cells as a target of MicroRNA-23a (miR-23a) [107]. This evidence concerns the gene PPP2R2A and neoplasm.