Indeed, when loss of ZEB1 expression was stratified with CD133 expression (Fig. 5a, hazard ratio 1.73, 0.95% CI, 1.28–2.34; **P = 0.0003) the result was shortened patient survival, suggesting that the effect of ZEB1 loss on survival was consistent with an increase in the proportion of the glioma stem cell population in the tumor. The gene discussed is PROM1; the disease is neoplasm.