To check whether ZEB1 binds and represses CDKN1A and CDKN2A genes in human tumor cells, we conducted ChIP assays and found that ZEB1 was indeed bound to CDKN1A promoter (Fig. 6N), implying a direct regulatory role for ZEB1 to promote cell proliferation in UM cells. This evidence concerns the gene CDKN1A and neoplasm.