TWIST1 and neoplasm: Unlike carcinoma where EMT-TFs like SNAI, ZEB, and TWIST families are critical in tumorigenesis by switching the tumor towards mesenchymal phenotype, the spindle (mesenchymal-like) phenotype of UM is known for decades as a clinicopathologic factor indicative of decreased malignancy as compared to the aggressive epithelioid (epithelial-like) phenotype16–18.