Adherent cells are anchored firmly by cell-cell and cell-extracellular matrix contacts through membrane adhesion molecules like E-cadherin (CDH1) for cell-cell conjunction, and integrins to connect the cytoskeleton to the matrix fibronectin (FN1), lacking such adherers would facilitate tumor cell dissemination both locally and in distance47. The gene discussed is CDH1; the disease is neoplasm.