It is of note that UM is a non-epithelial cell-derived tumor and epithelioid UM cells are just epithelial-like, whether or not the expression of epithelial marker E-cadherin (CDH1), a tumor repressor for carcinomas, and mesenchymal cell markers like N-cadherin (CDH2), a tumor progression facilitator for carcinomas, also correlates with the malignancy of UM is not clear. This evidence concerns the gene CDH2 and carcinoma.