DGIdb (v2014) reported ten genes that interacted with the small molecule kinase inhibitor Roniciclib, five of which were over-expressed in HR-NB patients and five of which (CCND1, CCND2, CDK1, CDK4 and c-Myc) belonged to the ESC-like cancer-activated signature5. The gene discussed is CDK4; the disease is neuroblastoma.