In this research, we investigated the regulation by cisplatin on PKC β, on B-cell lymphoma 2 (Bcl-2) and on apoptosis in cervical cancer Hela cells, examined the regulation by cisplatin on autophagy and the role of autophagy on the chemotherapy and investigated the regulation of the PKC β on the autophagy. The gene discussed is BCL2; the disease is cervical carcinoma.