The Müller cells were isolated from STZ-induced DM mice or citrate buffer injected mice (control) after mice were injected with STZ or citrate buffer for 1, 3, 5 and 7 month.s Results demonstrated that the expressions of MIAT mRNA in STZ-induced DM mice were 2.5-, 2.8-, 3.1- and 2.9-fold and that of control in 1, 3, 5 and 7 months respectively (Figure 1A). This evidence concerns the gene MIAT and diabetes mellitus.