Although the brunt of the current focus of overexpression of KDM3A in various types of cancer has been on its transcriptional targets (Krieg et al., 2010; Uemura et al., 2010; Cho et al., 2012; Osawa et al., 2013; Tee et al., 2014; Parrish et al., 2015), our work suggests that cytoplasmic KDM3A may act as an important cytoskeletal rheostat integrating mechanosensation (Kaukonen et al., 2016; Pedanou et al., 2016) with cell adhesion and signaling through cilia. Here, KDM3A is linked to cancer.