PGR and breast carcinoma: We found strong evidence to support the association between weight gain in adults and postmenopausal breast cancer, but weight gain is probably linked to environmental factors that are not captured by genetic risk factors.96 Moreover, some evidence exists that these associations may differ according to oestrogen and progesterone receptor status of the tumour (supplementary tables 6 and 7),68, 97 but large investigations in this area are lacking.