Studies have shown increased expression of several IFN-regulatory genes, including sialic acid-binding Ig-like lectin 1 Siglec1/CD169 (Siglec1), a marker of activated monocytes/macrophages, and numerous monocyte inflammatory cytokines in peripheral blood mononuclear cells (PBMCs) and sera from SSc patients, implicating dysregulation of the innate immune response in the activation of these cells [8–11]. Here, SIGLEC1 is linked to systemic sclerosis.