Consistent with the observation that TLR8 upregulation inhibits the TLR7-IFNα response, we found that expression of the BFRF1/lytic gene was associated with a trend of TLR7 downregulation in certain infected HD and dcSSc monocytes (Additional file 1: Figure S8), suggesting that activation of TLR8 may be a new strategy employed by EBV to dampen IFNα during lytic replication and control the host innate immune system. The gene discussed is TLR7; the disease is Huntington disease.