Of the 38 individuals in this group, 10 were found to be ANA+ after recruitment as HC, 4 after delivery of an infant with neonatal lupus or congenital heart block (all anti-Ro antibody–positive), 15 following investigation for arthralgia/myalgia, 6 following investigation for skin symptoms and 3 following investigation for other symptoms (1 eye symptoms, 1 white digits in the absence of Raynaud’s phenomenon and 1 headache). The gene discussed is CALR; the disease is congenital heart block.