EIF2AK2 and systemic lupus erythematosus: Therefore, to determine whether the IFN signature seen in ANA+ individuals that lack a SARD diagnosis differs from that seen in early SARD, expression levels of two genes that are contained within the cluster of genes that have been reported to be induced by IFN-β and elevated in patients with SLE who have higher levels of IFN-induced gene expression [17], EIF2AK2 and PLSCR1, were examined.