AHR and neoplasm: Other important deregulated pathways in all four localities were ABC transporters (involved in the translocation of exogenous and endogenous metabolites across membranes and DNA repair), the Wnt and TGF-β signaling pathways (associated particularly with tumor promotion and progression), steroid hormone biosynthesis (pathways involved in the endocrine-disrupting chemicals activity), and glycerolipid metabolism (pathways associated with the lipids with a glycerol backbone), which suggested a prominent role of the activation of aryl hydrocarbon receptor-dependent gene expression [48].