Consistent with the role of TAMs in driving angiogenesis and vascular remodeling, deletion of MYC in macrophage blocks the expression of VEGF and other pro-angiogenic molecules including matrix metalloproteinases-9 (MMP9), hypoxia-inducible factor-1α (HIF-1α), and transforming growth factor- β (TGF-β), collectively leading to the impairment of tumor angiogenesis [72,73]. This evidence concerns the gene MMP9 and neoplasm.