The dosages in the previous clinical trials of rAd-p53 varied dramatically, from 1–4 × 1012 viral particles per site [8,22,24,25,26,27,28,29,30,31,32,33,34,35,36,37], which were calculated based on the tumor sizes, the medical direction, and the researchers’ personal experiences. Here, TP53 is linked to neoplasm.