TIAM1 and breast neoplasm: With regard to the specific targets predicted to TNBC, TIAM1 encodes Tiam1 (T-lymphoma invasion and metastasis 1), one of the known guanine nucleotide (GDP/GTP) exchange factors (GEFs) for Rho GTPases (e.g., Rac1) and is expressed in breast tumor cells (e.g., SP-1 cell line).