Most importantly, there are several genes that can distinguish the four breast cancer subtype as specific therapeutic targets for each subtype, including EFCAB2 for luminal A, ATG16L2 for luminal B, C1QTNF6 and NDUFS6 for HER2+, as well as CHERP, TIAM1, and GABRP for TNBC (Table 1). This evidence concerns the gene TIAM1 and breast cancer.