However, at the time that this manuscript was being prepared for publication, a search of the PubMed database did not reveal any published studies pertaining to the direct effect of suppressing PIAS on JAK/STAT signaling in RA or the extent to which PIAS was altered in either OA synovial tissue, subchondral bone or articular cartilage. This evidence concerns the gene SOAT1 and rheumatoid arthritis.