MMP13 and chondrosarcoma: For example, Lim and Kim [50] showed that MMP-13 (i.e., collagenase-3) expression in an IL-1β–treated human chondrosarcoma cell line (employed as a surrogate for human chondrocytes) induced JAK2 and STAT-1/STAT-2 activation as well as MMP-13 gene expression which was blocked by the pan-tyrosine kinase inhibitor AG490.