SOAT1 and cancer: At approximately the same time that constitutive STAT protein activation was discovered to be a mechanism associated with the aberrant survival of cells in several chronic disorders including various types of cancer [35,36,37] and human immunodeficiency virus (HIV)-1 [38], up-regulation of the SOCS protein class in these conditions was also identified, which was accompanied by the activation of JAK/STAT via the action of various cytokines.