Of note, the results of a study reported by Choe et al. [45] indicated that Receptor Activator of Nuclear Factor-κB Ligand (RANKL) expression, which in RA contributes to the elevated level of osteoclast differentiation, is regulated by the IL-6/soluble IL-6 receptor, the JAK2/STAT3/SOCS-3 pathway. This evidence concerns the gene STAT3 and rheumatoid arthritis.