ANXA5 and Bloom syndrome: As shown in Figure 3, in the BLM treatment alone and BLM + CISCFE-M combined group, the rate of apoptotic cells (Annexin V+/PI− + Annexin V+/PI+) was notably increased as compared to the model group (all p < 0.05); the rate of apoptotic cells was obviously increased in the BLM + CISCFE-M combined group as compared to BLM alone (p < 0.05).