In conclusion, in a population of 141 non-diabetic adult individuals with no known psychiatric or neurological disease, we have found an association between altered gene expression in prefrontal cortex and increasing BMI levels involving a decreased mRNA expression of IL10 and an increased mRNA expression of NOS2 (iNOS) despite indication of an age-related downregulation of this gene in our population. The gene discussed is NOS2; the disease is nervous system disorder.