INS and neoplasm: Given the role of ADAMTS9 in such a wide range of age-related conditions, its direct effect on lifespan in C. elegans and its ability to modulate mTOR and insulin/IGF-1 signaling, it is likely that the convergent evolution of ADAMTS9 may be, in part, responsible for the exceptional longevity and resistance to neoplasia found in microbats and the naked mole-rat.