We found that all of the cell‐cycle‐associated cyclins (A, B, D1 and E), activated CDK1 (CDK1pT161) and CDK7 (which involves in the phosphorylation of CDK1pT161) were significantly up‐regulated in Pkd2‐null renal cells and in the tissue of our ADPKD model mice and that these cyclins and CDK7/CDK1 were down‐regulated by rapamycin treatment. Here, PKD2 is linked to autosomal dominant polycystic kidney disease.