By cross‐mating Pkd2f3/f3 mice with Cre transgenic mice driven by various kidney‐related promoters, including γGt‐Cre, Ksp‐Cre, Nestin‐Cre and Vil‐Cre mice (Table 1), we found that the Vil‐Cre;Pkd2f3/f3 mice developed disease phenotypes that were similar to human ADPKD (Fig. 1). Here, NES is linked to autosomal dominant polycystic kidney disease.