PRAME and seminoma: In consequence, this leads to up‐regulation of SOX2 and down‐regulation of SOX17. SOX2 triggers the induction of typical EC, pluripotency and epigenetic reprogramming factors, like GDF3, DPPA3, NODAL, ZIC3 and ZFP42 (REX1), whereas PGC / GCNIS / seminoma markers are down‐regulated (SOX17, PRAME, cKIT, PRDM1) 41.