Nonetheless, the data presented herein using androgen‐independent and androgen‐sensitive prostate cancer cell lines (PC3 and LNCaP) demonstrate that IGF1 and/or insulin can similarly modulate some parameters related to prostate cancer pathophysiology such as proliferation and expression of relevant receptors (INSR, IGFR or GHR), and therefore, we might speculate that these actions of insulin and IGF1 might be androgen independent. The gene discussed is INSR; the disease is prostate cancer.