Altogether, the data presented herein demonstrate, for the first time, that the PG becomes severely insulin resistant under diet‐induced obesity in mice and that most of the components of the GH, insulin and IGF1 regulatory axis are present in the PG, wherein their expression pattern is altered under diet‐induced obesity and after an acute insulin treatment. Here, IGF1 is linked to obesity due to melanocortin 4 receptor deficiency.