These latter results might be of particular interest, owing to the fact that it has been demonstrated that GH, IGF1 and insulin axes play a direct role in the control of the pathophysiology of prostate cells and, therefore, any dysregulation in the normal expression pattern of these regulatory systems, as the observed under obesity conditions in this study might have some potential pathological implications. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.