Interestingly, obesity did not alter drastically the expression levels of some of these components except for an increase in Igfbp3, a decrease in Glut4, and a non‐significant reduction in Ghr (P = 0.08) levels in the PGs of HFD‐fed mice compared to LFD‐fed mice (vehicle‐treated; Fig. 3A, white columns). The gene discussed is IGFBP3; the disease is obesity due to melanocortin 4 receptor deficiency.