For this reason, we have used here a combination of molecular, cellular and whole‐animal approaches to study the influence of diet‐induced obesity on PG insulin management, and on the gene expression profile of the components of the GH/IGF1/insulin systems at the PG level, as well as the direct role of these hormones (insulin and IGF‐I) in normal and tumoral prostate cells. Here, GH1 is linked to obesity disorder.