INS and intraepithelial neoplasia: In line with this, insulin has also been shown to be crucial for the correct development of the PG, inasmuch as lack of insulin in non‐obese diabetic mice affects the morphology and function of PGs promoting atrophy of secretory epithelial cells and stroma hypertrophy, leading to development of intraepithelial neoplasia, inflammation and alteration of the secretory process 19.