INS and Insulin resistance: Interestingly, we found a significant negative correlation between the BW of HFD‐fed mice and the response to insulin injection (activation of AKT signalling) in the liver (R = −0.916, P = 0.029), whereas this effect was not as obvious in PGs (R = −0.630, P = 0.254) (Fig. 2C) which might suggest the existence of a tissue‐dependent association between BW and insulin resistance under HFD conditions.