SOD1 and amyotrophic lateral sclerosis: Oligodendrocytic expression of mutant SOD1 appears to play a critical role in mutant SOD1-ALS [41, 47, 63], and our current study provides suggestive, but not conclusive, evidence for a critical role of oligodendrocytes in ALS-FUS, and it does not identify pathogenic mechanisms elicited by mutant FUS in myelinating cells.