PMP22 and Charcot-Marie-Tooth disease: For instance, decreases in PMP2, whose mutations can cause demyelinating Charcot–Marie–Tooth disease (CMT) [57] is sufficient to modify the lipidome of peripheral myelin [94], while heterozygous loss of Pmp22, causing human peripheral neuropathy [60], disrupts myelin junctions in mice [28, 33].