In terms of prevention of postoperative worsening of DME and improvement of the final visual outcome, it is advisable to inject an intravitreal anti-VEGF drug during cataract operation in patients with preexistent diabetic macular edema [13, 25, 26], and there are clinical studies done proving that even patients with stable diabetic retinopathy without significant macular edema do benefit from this procedure in terms of less thickening of the macula and better visual outcome [13, 27]. This evidence concerns the gene VEGFA and diabetic macular edema.