In fact, some evidence suggests that 10–15 mg/kg of memantine may minimize schizophrenia-like symptoms in ketamine-induced model in rats [42] while 20 mg/kg of memantine seems to impair rather than ameliorate cognitive function [43, 44] but memantine (5 mg/kg) did not increase Homer1a signal [22]. Here, HOMER1 is linked to schizophrenia.