7 We had previously evaluated the amount of NO released by cancer cells grown in our culture medium, and found that the concentration of NO released by cancer cells in our culture medium was 10% of that released by cells which had been treated with 100 μM DETA-NONOate (~40 nM NO) under the same conditions.20,21 This concentration of NO is much lower than that released by NOS2 under conditions of inflammatory stimulation. Here, NOS2 is linked to cancer.