The AKT/mTOR signaling pathway is constitutively activated in nasopharyngeal carcinoma (NPC) tissue.24 To investigate whether the role played by NOS1 in autophagy inhibition depends on activation of AKT/mTOR signaling, we evaluated the effect of NOS1 on AKT/mTOR signaling induced by NOS1 siRNA, as well as by overexpression of NOS1. This evidence concerns the gene MTOR and nasopharyngeal carcinoma.