AKT1 and cancer: Moreover, NPC has been consistently associated with the Epstein–Barr virus.32 The PI3K-AKT-mTOR signaling pathway is frequently activated in cases of NPC, and this activation is critical for cancer cell survival; however, it is also correlated with a poor clinical prognosis.24 The EBV latent membrane proteins LMP1 and LMP2A are capable of inactivating PTEN,33 which is an important tumor suppressor protein in various types of cancer cells.