Moreover, NPC has been consistently associated with the Epstein–Barr virus.32 The PI3K-AKT-mTOR signaling pathway is frequently activated in cases of NPC, and this activation is critical for cancer cell survival; however, it is also correlated with a poor clinical prognosis.24 The EBV latent membrane proteins LMP1 and LMP2A are capable of inactivating PTEN,33 which is an important tumor suppressor protein in various types of cancer cells. This evidence concerns the gene PTEN and cancer.