Figure 4 showed that the number of macrophages in tumor microenvironment was decreased in the LV-gra15II-Mφ treated group, and reduced expression of IL-10, TGF-β, and VEGF in tumor tissues and increased expression of MHCII molecule in the animals that received LV-gra15II-Mφ inoculations, compared with the group treated with LV-Mφ. The gene discussed is IL10; the disease is neoplasm.