We conclude that ToxoGRA15II, as a strong inducer of classically activated macrophages and an applicable peptide derived from T. gondii, may have a potential role in increasing early antitumor immunity due to its ability to indigenously activate NF-κB signaling in macrophages and synchronically induce both highly potent innate as well as adaptive immune mechanisms for cancer therapy. Here, NFKB1 is linked to cancer.