Antibody responses against P. vivax CSP-1 (77), PvMSP-1 (78–81), PvRBP1 (82, 83), PvAMA-1 (84), and PvMSP-3α (85, 86) have been characterized by IgG1 and IgG3 predominance, which are associated with malaria exposure and malaria protection; Tables 1 and 2 summaries the results obtained in each study. This evidence concerns the gene CSP1 and malaria.