On the other hand, studies performed in cancer cells showed that RXRs are targeted by the CK1 family, and precisely RXR is bound and phosphorylated by CK1α in an agonist-dependent manner (31), as well as by GSK3β, with modulation of cell predisposition to RXR agonist-induced growth arrest and apoptosis and support of cell survival (32). The gene discussed is CSNK1A1; the disease is cancer.