EDN1 and Hypertension: 2011). ET‐1 reduces Na+ and water reabsorption in the CD via inhibition of the epithelial Na+ channel (ENaC), the Na+/K+ ATPase, and vasopressin (AVP)‐stimulated adenylyl cyclase activity (Tomita et al. 1990, 1993; Bugaj et al. 2008; Pavlov et al. 2010). CD‐specific knockout of ET‐1 causes renal Na+ and water retention, and hypertension (Ahn et al. 2004; Ge et al. 2005).