We have reported a phase II study (VENUS-PC study) in which three epitope peptides (one derived from oncoantigen KIF20A (RAB6KIFL)[20] and two derived from vascular endothelial growth factor receptors (VEGFRs)[21, 22]) in combination with GEM were applied to advanced PC patients [23]. This evidence concerns the gene KIF20A and pachyonychia congenita.