Second, the downregulated YAP1 expression in colon cancer cells by either gene-silencing technique or phytochemical treatment of ovatodiolide led to the decreased tumorigenesis (colony formation, migration, and tumor sphere formation) accompanied by the decreased M2-polarizing cytokines such as IL-4 (the major one affected by YAP1 silencing) and IL-13 (to a lesser extent) as well as mTOR/Akt signaling. The gene discussed is YAP1; the disease is malignant colon neoplasm.