Our findings suggest that YAP1 within the tumor cells may function in promoting colon tumorigenesis via its association with aforementioned oncogenic pathways and generating cancer stem-like cells (as shown in our study) while generating M2 TAMs via increased M2-polarizing IL-4 and IL-13 cytokines into the stroma (Fig. 8d for proposed model). This evidence concerns the gene IL4 and neoplasm.