IL6 and cancer: In addition, ovatodiolide-mediated IL-6 suppression in the M2 TAMs represented another important anti-cancer attribute of ovatodiolide; even in the presence of exogenous IL-6 which increased the generation of cancer stem-like cell population in both HCT116 and DLD-1 cell lines, ovatodiolide was able to attenuate IL-6’s effects.