OV-mediated anti-CRC effects were found in association with the decreased expression of YAP1, Kras/MEK/ERK, NF-kB, mTOR (oncogenic markers), β-catenin, and Notch1 (stemness markers) while an increased in Bax expression (pro-apoptosis marker). The gene discussed is MAP2K7; the disease is colorectal carcinoma.