TNF and neoplasm: Genetic analysis has revealed that TAMs can produce VEGF, TNF-α, IL-1β, IL-8 (CXCL8), platelet-derived growth factor (PDGF), basic fibroblast growth factor (bFGF), thymidine phosphorylase, MMPs, and other molecules that are involved in tumor angiogenesis, indicating that TAMs promote the formation of intratumoral blood vessels that provide nutrition for tumor growth [45].