As shown in Fig.5b ~ f and Additional file 1: Figure S11B ~ F, both the enforced expression of miR-30d and the knockdown of MYPT1 significantly activated c-JUN and increased the expression of VEGFA protein, implying that c-JUN and VEGFA might function as the downstream effectors of miR-30d-MYPT1 axis in human PCa cells and be implicated in tumor angiogenesis during PCa progression. This evidence concerns the gene PPP1R12A and neoplasm.