RHOA and neoplasm: After the pathway enrichment analysis based on KEGG database, we found that the above 36 putative targets of miR-30d were significantly associated with several tumor-related pathways, such as RhoA signaling, DNA methylation and transcriptional repression signaling, Signaling by Rho family GTPases and PI3K/AKT signaling (Additional file 3: Table S7 and Additional file 1: Figure S7), which all have broad effects on cell behavior.