Then, the data shown in Additional file 3: Table S8 revealed that low IRS of MYPT1 protein was significantly associated with high Gleason score (P = 0.002), positive metastasis (P = 0.018) and BCR (P < 0.001) and shorter overall survival (P = 0.005) of PCa patients. This evidence concerns the gene PPP1R12A and posterior cortical atrophy.