This genetic link between EBNA2 polymorphism and MS again deserves further interest since EBNA-2 directly interacts with the cellular DNA-binding protein RBPJ-κ (recombination signal-binding protein J kappa), a ubiquitous protein of the Notch signalling pathway that plays an important role in Epstein-Barr virus infection. The gene discussed is RBPJ; the disease is Epstein-Barr virus infection.