If NF-κB induces phosphorylation and activation of the signal transducer and activator of transcription 1 (STAT1) in B-CLL cells, cleavage and apoptosis are induced via the activation of caspases and poly(ADP-ribose) polymerase [15] (Fig. 3). The gene discussed is STAT1; the disease is B-cell chronic lymphocytic leukemia.