Apart from improving the chemotherapeutic agents’ effects, CpG ODNs also improve radiotherapy outcomes of both immunogenic and non-immunogenic with a high complete tumor remission rate [17, 89] by exerting direct effects on human malignant B cells and indirect effects on the immune system with an increase in the number of tumor-reactive memory CD8+ T cells, leading to enhanced antitumor immunity [18, 90, 91]. Here, CD8A is linked to neoplasm.