In this case, phosphorylation of ezrin (of the ezrin-radixin-moesin family of adapter molecules, required for cancer cell invasion) in response to EGF requires SK2 and intracellular S1P2 and involves an intracrine action of intracellular S1P possibly made available by a close proximity localisation of Spns2 with S1P2 in endosomes [46]. The gene discussed is EZR; the disease is cancer.