Despite the ability of these fatty acids to modulate in an antineoplastic sense cancer apoptosis, cell differentiation, proliferation, migration, neo-angiogenesis, invasion, and metastasis in a variety of cancer cells being related in most cases to ERK1/2 or/and Akt inactivation, some results have demonstrated that LCn-3 PUFA may, on the other hand, drive their activation, thus suggesting that the mechanisms of their action may be tissue- or cancer-specific [48]. Here, MAPK3 is linked to cancer.