A second study [91] also deserves further attention since, differently from all the other reports analyzed, it showed that very high and cytotoxic doses of LCn-3 PUFA were able to attenuate apoptosis induced by the anti-estrogenic drug Tamoxifen in breast cancer cells, and that the effect was related to the very early and transient increase of p-ERK and p-Akt expression observed. This evidence concerns the gene AKT1 and breast cancer.