Consistently, the results recently obtained by Hopkins et al. [64] indirectly suggested that the observed EPA ability to inhibit LPA- and EGF-induced proliferation of both MDA-MB-231 cells and MCF-7 cells could be ascribed to the inhibitory action of EPA on the phosphorylation/activation of ERK1/2 and Akt, which, on the contrary, was markedly stimulated by LPA and EGF in these cancer cells. The gene discussed is EGF; the disease is cancer.