Fibrillary collagen 5 mRNA was increased by hyperglycemia (1.03 ± 0.03 vs. 0.71 ± 0.05 a.u., p < 0.001, WT 25 mM vs. WT 5 mM) and 1.4-fold elevated by GLO1 knockdown (1.44 ± 0.06 a.u. vs. 1.00 ± 0.01 a.u., p < 0.0001, WT 25 mM + GLO1-siRNA vs. WT 25 mM + NT-siRNA), whereas collagen 5 protein was unchanged (Figure 4e,f). The gene discussed is GLO1; the disease is Hyperglycemia.