A silent, subclinical (smoldering) inflammation with increased C-reactive protein (CRP), present in many solid tumors and well described in pancreatic cancer [18], also contributes, to a certain degree, to both energy expenditure and loss of appetite; indeed, elevated CRP levels can be used as a marker for cachexia in pancreatic cancer [19] and can even predict a poor prognosis [20]. The gene discussed is CRP; the disease is familial pancreatic carcinoma.