CEACAM5 and metastatic malignant neoplasm in the lymph nodes: However, there is a tendency that PAX1 methylation level was associated with TNM stage and lymph node metastasis with a p value of 0.068 and 0.073, respectively, while ZNF582 methylation level was associated with carcino-embryonic antigen (CEA) concentration with a p value of 0.076 (Table 4).