KLK3 and neoplasm: Active surveillance may be best for patients with low-risk disease (i.e., Gleason score of 6 or less), whereas men with high-risk disease (i.e., Gleason score >7, PSA levels >20 ng/mL and clinical tumour stage >pT2c, i.e., tumour involving both prostate lobes) will rather benefit from radical prostatectomy or radiotherapy [12].