Some possible mechanisms may explain the plasma zinc concentration observed in our study: (1) zinc mobilization among cell compartments, plasma, the liver, and the bone [46]; (2) the excretion of this mineral by the gastrointestinal tract, as zinc excretion via the intestinal lumen might be decreased, which would then reduce endogenous losses through feces [21]; and (3) hyperglycemia, which is common in patients with MS and may stimulate insulin secretion, where part of the zinc pool found in beta cells is secreted into the plasma together with the hormone [4]. Here, INS is linked to Hyperglycemia.