EGFR and urinary bladder cancer: Those known to involve bladder cancer cell proliferation/migration/invasion as well as angiogenesis/metastasis include β-catenin/Wnt signaling and its downstream targets c-myc/cyclin D1 [65,81,84,86], CD24 [80,88], EGFR family and its downstream AKT/ERK [39,79], ELK1 [82], matrix metalloproteinases (MMPs) [45,65,83,86,88,93], and vascular endothelial growth factor [45,88].