SOD2 and Retinal atrophy: For example, mice knocked-in for the APOE4 gene and fed a diet high in fat and cholesterol exhibit drusen-like structures and retinal atrophy as well as signs of choroidal neovascularization.38 The retinal oxidative stress in our mouse model is caused by RPE-specific deletion of Sod2 using the cre-lox system.10 These mice exhibit an age-related decline in the scotopic a-wave and b-wave gradual thinning of the outer nuclear layer.