Diverse single nucleotide polymorphisms (SNPs) in genes such as HLA-I, HLA-II, TNF-α, IL-10, TGF-β1, FcγRIIa, VDR, CD209 and OAS have been associated with symptomatic dengue or considered protective against the disease, in Asian and Latin American populations [3]. The gene discussed is TNF; the disease is dengue disease.